Maitake - Grifola Frondosa
- eshed haklai
- Oct 21, 2025
- 2 min read
Updated: Dec 30, 2025
Maitake is considered one of the most important medicinal mushrooms in Japan, China, and the West. Its Japanese name, meaning “Dancing Mushroom,” comes from a legend in which these rare mountain mushrooms were so precious that people danced with joy upon finding them. In the West, Maitake is best known for its effects on metabolism, blood sugar and lipid balance, and immune support. In traditional Asian medicine, it is regarded as a medicinal food that strengthens Qi, supports liver function, reduces phlegm and dampness, and balances digestive energy. Traditional uses include support for chronic fatigue, obesity, high blood pressure, and recovery after long-term illnesses.

Key Active Compounds:
Specific beta-glucans:
D-fraction, MD-fraction: Clinically studied, shown to stimulate macrophages, NK cells, and lymphocytes.
SX-fraction: A unique extract approved in Japan as an adjunct treatment for type 2 diabetes due to its effects on insulin sensitivity and blood glucose reduction.
Ergosterol: A natural precursor of vitamin D, with antioxidant and anti-inflammatory properties.
Polysaccharide Grifolan: Demonstrated anti-cancer activity and immune modulation in preclinical studies.
Fatty acids and phenolic compounds: Provide liver protection and antioxidant effects.
Evidence-Based Medical Properties:
Immune system: Regulates immune function related to white blood cells and inflammatory mechanisms. Clinical studies in cancer patients (mainly breast, lung, and prostate) showed improved immune markers, tumor growth inhibition, and enhanced cancer cell killing when combined with chemotherapy.
Blood lipid profile: Studies indicate reductions in cholesterol and triglycerides and protection of blood vessels from lipid oxidation.
Nervous system: Exhibits neuroprotective activity, reduces neuroinflammation, and provides antioxidant support to the nervous system.
Summary:
Maitake is one of the most documented and effective mushrooms in natural medicine. Research has demonstrated its potential in:
Oncology: Especially as an adjunct to conventional cancer therapies
Metabolism: Supporting blood lipid balance, fatty liver, and diabetes
Immune system regulation
Hormonal balance
Additional properties include antiviral activity, support for Candida-related conditions, digestive system recovery, and more.
Warnings:
Generally considered safe, even for long-term use.
Diabetes: May lower blood glucose levels, require caution when combine with diabetic medications.
Avoid use during immunosuppressive therapy unless directed by a healthcare professional.
Pregnancy and breastfeeding: Insufficient research; consult a qualified practitioner or physician. For further questions, please contact us and provide details of your inquiry.



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